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|Usage:||Weight Loss; Fat Burning; Fitness; Bodybuilding||CAS No.:||125-69-9|
|Quality:||USP Grade Product||Shipment:||EMS, DHL, TNT, FEDEX, UPS|
Product Name:Dextromethorphan Hydrobromide
Alias :Dextromethorphan Hbr , Dextromethorphan Hydrobromicum , Dextromethorphan Hydrobromide , , Romilar
Appearance:White or kind of white crystalline powder, soluble in water.
Dextromethorphan (DXM or DM) is an antitussive (cough suppressant) drug. It is one of the active ingredients in many over-thecounter cold and cough medicines, including generic labels and store brands, Benylin DM, Mucinex DM, Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, TheraFlu, and others. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychological applications. It is sold in syrup, tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder.
DXM is also used recreationally.When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen.Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist.The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist.In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic such as and .As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.
1. For dry cough, including upper respiratory tract infection (such as cold, pharyngitis, bronchitis, cough).
2. Research reagents, widely used in molecular biology, pharmacology research. This is the central antitussive, can inhibit the medulla cough centrum antitussive effect and produce. The antitussive effect is equal to or slightly. The general treatment dose not inhibit respiration, long-term use of no addiction and tolerance.
Generic Dextromethorphan syrup.
The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants.
A 2004 study showed that dextromethorphan was no more effective for children than a placebo.Studies conducted by the American Academy of Pediatrics show that dextromethorphan is not superior to a placebo in providing nocturnal symptom relief for children with cough and sleep difficulty due to upper respiratory infections.
A combination of dextromethorphan and quinidine, a CYP2D6 inhibitor, has been shown to alleviate symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis.Dextromethorphan is also being investigated as a possible treatment for neuropathic pain and pain associated with fibromyalgia.In 2010, the FDA approved the combination product dextromethorphan/quinidine (Nuedexta) for the treatment of pseudobulbar affect (PBA).
Dextromethorphan has been shown to be effective in treating opioid withdrawal. At doses of 2 mg/kg in rats all signs of opioid withdrawal were eliminated.
|Apperance||Practically white crystal or
|White crystalline powder|
|Identification||A. FT-IR||The sample spectrum correspond to
that of the reference standard
|B. UV||Not more than 3.0% difference
of RS(on anhydrous basis)
|C. Bromide Test||Yellow white precipitate formed||Conforms|
|Specific rotation A||1.8w/v in water:Not more than 1.0%
difference of RS
At 325nm and 25ºC(on anhydrous basis)
|Specific rotation B||2.0%w/v in 0.1M HCL: +28ºCto +30ºC
at 589nm and 20ºC(on anhydrous basis)
|Clarity of solution||5.0%w/v in alcohol:Clear and colorless||Conforms|
|PH||5.2-6.5(1 in 100 water solution)||6.1|
|Acidity or Alkalinity||Not more than 0.4ml of
|Water(by KF Titration)||4.0%-5.5%||5.0%|
|a)For each of impurities A,B,C,D
not more than 0.5%
|b)Among impurities A,B,C,D not
more than one greater than 0.25%
|C)For each of unspecified impurities,
not more than0.10%
|d)Total impurities not more than 1.0%||<0.05%|
|Residue on Ignition||Not more than 1.0%||0.05%|
|N,N-Dimethylaniline||Not more than 0.001%||Conforms|
|Phenolic compounds||No blue-green color develops||Conforms|
|Assay A (by HPLC)||98.0%~102.0%(on anhydrous basis)||100.0%|
|Assay B(by titration)||99.0%~101.0%(on anhydrous basis)||100.4%|
|Storage||Preserve in tight containers;
protected from light
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