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|Grade Standard:||USP||Cas No.:||33069-62-4|
|Shelf Life:||2 Years||Product Name:||Paclitaxel|
|Application:||Pharmaceutical Raw Powder||Email:||Juliesupplier@chembj.com|
|Origin||Yew Taxus plants dried roots, leaves and bark|
|Appearance||White crystalline powder|
|Related substances||≤ 2.0% of total related substances|
|Organic volatile impurities||Complies with United States Pharmacopeia (USP) and the Chinese Pharmacopoeia (CP) Organic volatile impurities requirements.|
|Specific rotation||[α ] 20 D = -49.0 ° ~ 55.0 ° (10mg/mL solution in methanol), anhydrous solvent dry product.|
|Residue on ignition||≤ 0.2%|
|Heavy metals||≤ 0.002%|
|Microbial limit||≤ 100cfu / g paclitaxel; Meet on Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella, Enterobacter sterility test requirements of people.|
Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel.Paclitaxel is used to treat patients with lung, ovarian, breast, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.
Paclitaxe powder is a chemotherapy drug that is given as a treatment for some types of cancer. Paclitaxe powder is a mitotic inhibitor now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxe is also used for the prevention of restenosis.
Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes. It was the subject of a notable total syn
thesis by Robert A. Holton.
1. Paclitaxe is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Paclitaxe has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.