Payment & Shipping Terms:
|Grade Standard:||USP||Cas No.:||143-67-9|
|Shelf Life:||2 Years||Product Name:||Vinblastine Sulfate|
|Application:||Pharmaceutical Raw Powder||Email:||Juliesupplier@chembj.com|
Vincristine Sulfate, USP is a white to off-white powder. It is soluble in methanol, freely soluble in water, but only slightly soluble in 95% ethanol. In 98% ethanol, Vincristine Sulfate, USP has an ultraviolet spectrum with maxima at 221 nm (ε¸+47,100).
Vincristine Sulfate Injection, USP (vincristine sulfate) is a sterile, preservative-free, single use only solution available for intravenous use in 2 mL (1 mg and 2 mg) vials. Each mL contains 1 mg Vincristine Sulfate, USP, 100 mg mannitol and Water for Injection, USP q.s. Sulfuric acid or sodium hydroxide have been added for pH control. The pH of Vincristine Sulfate Injection, USP (vincristine sulfate) ranges from 4.0 to 5.0. At the time of manufacture, the air in the containers is replaced by nitrogen.
Therapeutic indications: Vinblastine sulphate is a cytotoxic drug that arrests cell growth at the metaphase. Its actions are more pronounced on the rapidly dividing cell than on the normal cell. It appears to act, like vincristine, by binding to the microtubular proteins of the mitotic spindle, preventing polymerisation.
Vinblastine sulphate is effective as a single agent, but its therapeutic effect is enhanced when used in combination with other antineoplastic drugs. Vinblastine sulphate has been used in the treatment of Hodgkin's disease (Stages III and IV); Lymphocytic lymphoma (nodular and diffuse, poorly and well differentiated); Histiocytic lymphoma; Advanced stages of mycosis fungoides; Advanced carcinoma of the testis; Kaposi's sarcoma and Letterer-Siwe disease (histocytosis X). Vinblastine sulphate may be used in the treatment of choriocarcinoma resistant to other chemotherapeutic agents; Carcinoma of the breast, unresponsive to appropriate endocrine surgery and hormonal therapy.
Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens. Its main uses are in non-Hodgkin's lymphoma as part of the chemotherapy regimen CHOP, Hodgkin's lymphoma as part of MOPP, COPP, BEACOPP, or the less popular Stanford V chemotherapy regimen in acute lymphoblastic leukemia (ALL), and in treatment for nephroblastoma.It is also used to induce remission in ALL with dexamethasone and L-Asparaginase, and in combination with prednisone to treat childhood leukemia.Vincristine is occasionally used as an immunosuppressant, for example, in treating thrombotic thrombocytopenic purpura (TTP) or chronic idiopathic thrombocytopenic purpura (ITP).
4. Other products:
|Procaine Hydrochloride||Lidocaine Hydrochloride||Prilocaine|
|Prilocaine Hydrochloride||Pramoxine||Pramoxine Hydrochloride|
|CJC-1295 NO DAC||CJC-1295 DAC||Deslorelin|